海洋来源微生物天然产物的发现与生物合成研究。

（1）海洋新药源分子的发现：采用随机筛选和基因组挖掘相结合的方法发现海洋微生物来源新药源分子，并提高其产量。

（2）海洋新功能酶的发现：揭示海洋微生物合成天然产物的新机制，发掘具有绿色催化功能的酶。

1. 国家自然科学基金面上项目，南海珊瑚共附生放线菌来源新化合物kongjuemycins的生物合成研究，2023.1.1-2026.12.31，54万元，在研，主持。

2. 国家自然科学基金面上项目，海洋来源新颖的脂肽类化合物Totopotensamides中脂肪链生物合成及后修饰研究, 2021.01.01-2024.12.31, 63万元, 在研, 主持。

3. 海南省自然科学基金面上项目，珊瑚共附生放线菌SCSIO 11457中抗珊瑚致病菌活性次级代谢产物的基因组挖掘，2021.6.1-2023.12.31，5万元，在研，主持。

4. 中国科学院南海海洋研究所南海新星项目，珊瑚共附生放线菌SCSIO 11457中抗珊瑚致病菌次级代谢产物的基因组挖掘和应用，2019.1.1-2023.12.31，60万元，在研，主持。

1.近五年发表文章47篇、授权专利13件，专著1种。

2.代表性论文（第一作者或通讯作者10篇）：

# (co-first author), * (corresponding author)

1. Bin Tan#, Liping Zhang#, Qingbo Zhang#, Siqiang Chen, Weiliang Xiong, Yiguang Zhu*, Changsheng Zhang*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, DOI: 10.1002/anie.202302043.

2. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang,* Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979-985.

3. Bin Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, (12): 1478–1484.

4.  Bin Tan, Qingbo Zhang,* Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84.

5. Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal macrolides kongjuemycins from coral-associated rare actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487.

6. Xiaodong Jiang,# Zhuangjie Fang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of a new asymmetric dimer nenestatin B and implications of dimerizing enzyme in a deep sea Actinomycete. Organic & Biomolecular Chemistry, 2021,19 (19): 4243-4247.

7. Yiguang Zhu,# Qingbo Zhang,# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,* and Changsheng Zhang*. Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069.

8. Zhuangjie Fang,# Xiaodong Jiang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130.

9. Bin Tan,# Qingbo Zhang,# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides. ACS Chemical Biology, 2020, 15 (3): 766-773.

10. Bin Tan,# Siqiang Chen,# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang and Changsheng Zhang*. Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066.